PATHFAST Presepsin in Patients with SIRS and Early Sepsis in the Emergency Department

Background: CD14 is expressed on the cell membrane of monocytes/macrophages and activates the TLR4-specific inflammatory reaction against infectious agents whereby soluble CD14 is released. During shedding from the cell surface sCD14 is split yielding the fragment sCD14-ST named presepsin. Presepsin serves as a mediator of the response to lipopolysaccharid from infectious agents. First evidence suggested that presepsin may be utilized as sepsis marker.