Presepsin and procalcitonin as predictors of sepsis based on the new Sepsis-3 definitions in obstructive acute pyelonephritis
Background: Acute pyelonephritis (APN) with obstructive uropathy often causes sepsis. Recently, sepsis was
redefined using the sequential organ failure assessment (SOFA) score, based on the new Sepsis-3 criteria. We
investigated predictors for sepsis using this new definition in patients with obstructive APN associated with upper
urinary tract calculi.
redefined using the sequential organ failure assessment (SOFA) score, based on the new Sepsis-3 criteria. We
investigated predictors for sepsis using this new definition in patients with obstructive APN associated with upper
urinary tract calculi.
Methods: We retrospectively evaluated patients who were admitted to our hospital for treatment of obstructive
APN associated with upper urinary tract calculi. Blood and urine samples were collected before treatment of
obstructive APN. Treatment included adequate antimicrobial therapy and emergency drainage to decompress the
renal collecting system. We diagnosed sepsis using the new Sepsis-3 definition. We assessed predictors for sepsis by
multivariate logistic regression analysis.
APN associated with upper urinary tract calculi. Blood and urine samples were collected before treatment of
obstructive APN. Treatment included adequate antimicrobial therapy and emergency drainage to decompress the
renal collecting system. We diagnosed sepsis using the new Sepsis-3 definition. We assessed predictors for sepsis by
multivariate logistic regression analysis.