Presepsin levels in cirrhotic patients with bacterial infections presented with or without acute kidney injury

Cirrhotic patients carry an increased risk to develop bacterial infections (BI), sepsis, severe sepsis and septic shock. Patients with liver cirrhosis are two times more likely to die from sepsis than patients without preexisting liver disease and septic shock in this population is associated with a hospital mortality that may surpass 70% [1]. Serum presepsin has recently aroused as a potential biomarker for sepsis diagnosis. Presepsin is a direct witness of activated monocytes macrophages in response to pathogens and is able not only to signal an earlier increase compared with CRP and PCT, but also to perform a unique capacity of distinguishing the severity of sepsis [2]. In this study we aimed to evaluate presepsin levels in a group of cirrhotic patients with compensated or decompensated liver disease, without documented BI and to identify potential correlations with the severity of liver disease, using well defined scores for patients with liver cirrhosis, such as Child-­Pugh and MELD score.
Moreover, we aimed to investigate the degree of change in presepsin levels with the presence of BI, portal hypertension related bleeding (PHRB) and acute kidney injury (AKI) [3].