Presepsin values as markers of severity of sepsis

Objectives: Biomarkers are widely used for rapid diagnosis of sepsis. This study evaluated the diagnostic
accuracy of presepsin, procalcitonin (PCT), and C-reactive protein (CRP) in differentiating sepsis severity
as well as their association with Sepsis-related Organ Failure Assessment (SOFA) score.

Methods: One hundred septic patients from two university clinical centers were enrolled in the study
during two time periods. New Sepsis-3 definitions were used for sepsis stratification. Biomarkers and
SOFA score were evaluated four times during the illness. A sandwich ELISA kit was used for presepsin
measurement. Generalized linear mixed effects model was used to test the changes in biomarkers
concentrations and SOFA score values during the illness and to estimate the differences between severity
groups. Multivariate analysis was used to test the association of biomarkers with SOFA score.