Serum prepsepsin (soluble cd14-subtype) as a novel useful biomaker for infection in patients with rheumatoid arthritis (ra)

Background: Infection is one of the serious complications seen in the management of RA patients. The acute inflammatory marker C-reactive protein (CRP) is elevated both during infection and during high disease activity of RA, and this often poses a problem when distinguishing the two. The soluble CD14 subtype, presepsin has been reported to be a novel effective marker for the diagnosis of sepsis but has not been evaluated in RA patients.