Soluble CD14-subtype (Prespsin) and Hepcidin as Diagnostic and Prognostic markers in Early Onset Neonatal Sepsis

Background: The clinical picture and laboratory markers of Early-onset neonatal sepsis
(EONS) are nonspecific, however a variety of different molecules have been suggested as
clinical biomarkers in sepsis. Presepsin (soluble CD14-subtype) has been identified as a
protein whose level increases significantly in the blood of septic patients. Hepcidin, an
iron homeostasis regulator, it can be used in diagnosis of neonatal sepsis.
The aim of this study is to evaluate the role of new markers namely presepsin and
hepcidin in diagnosis of EONS compared to CRP before and after antibiotic therapy.