Stimulation of sCD14-ST (Presepsin) Secretion By Peripheral Blood Mononuclear Cells after Candida Albicans Lysate and Lipopolysaccharide Exposure

Background: Сluster of differentiation 14 (CD14) is a specific high-affinity receptor for lipopolysaccharides (LPSs) on monocytes, macrophages and granulocytes. Soluble CD14 subtype (sCD14-ST, Presepsin) is a shortened soluble N-terminal fragment of CD14. Levels of sCD14-ST have a strong correlation with severe bacterial infection which can be used as diagnostic tool. However, CD14 recognize not only LPS, but also a variety of ligands associated also with Grampositive bacteria, fungi, and viruses. Here we report data about impact of C.albicans antigens on monocytes and presepsin level in vitro.