The Physiological Variation in Plasma Presepsin Levels During the Early Neonatal Period

Neonatal sepsis continues to be a global problem with significant morbidity and mortality. The evaluation of some biomarkers is useful for the diagnosis of sepsis because of the difficulty in predicting its onset by clinical symptoms alone. Peripheral white blood cell (WBC) counts and serum levels of C-reactive protein (CRP) and procalcitonin, the representative biomarkers for the diagnosis of bacterial infection, are elevated in the early neonatal period due to physiological variations and can peak at approximately 24 hours after birth (van Rossum et al. 2004; Hofer et al. 2011; Miyake et al. 2016). Therefore, attention should be paid to the interpretation of the elevation of these biomarkers durng the early neonatal period.