The Emerging Role of Presepsin (P-SEP) in the Diagnosis of Sepsis in the Critically Ill Infant: A Literature Review
Chiara Maddaloni 1, Domenico Umberto De Rose 1 , Alessandra Santisi 1, Ludovica Martini 1, Stefano Caoci 1, Iliana Bersani 1, Maria Paola Ronchetti 1,2 and Cinzia Auriti 1,*,†1 Neonatal Intensive Care Unit (NICU), Medical and Surgical Department of the Fetus—Newborn-Infant, “Bambino Gesù” Children’s Hospital IRCCS, 00165 Rome, Italy; chiara.maddaloni@opbg.net (C.M.); domenico.derose@opbg.net (D.U.D.R.); alessandra.santisi@opbg.net (A.S.); ludovica.martini@opbg.net (L.M.); stefano.caoci@opbg.net (S.C.); iliana.bersani@opbg.net (I.B.); mariapaola.ronchetti@opbg.net (M.P.R.)
2 Neonatal Intensive Care (NICU) and Neonatal Pathology, San Vincenzo Hospital, 98039 Taormina, Italy
Correspondence: cinzia.auriti@opbg.net; Tel.: +39-06-6859-2427; Fax: +39-06-6859-3916
† On behalf of the Study Group of Neonatal Infectious Diseases of the Italian Society of Neonatology (SIN)
The Role and Validity of Diagnostic Biomarkers in Late-Onset Neonatal Sepsis
Patience Mwesigye1, Fizza Rizwan2, Niazy Alassaf3, Rizwan Khan31 InternalMedicine,UniversityofLimerick,Limerick,IRL
2 InternalMedicine,MedicalUniversityofSofia,Sofia,BGR
3 Neonatology, University Maternity Hospital, Limerick, Limerick, IRL
Corresponding author: Patience Mwesigye, patiencehonors@gmail.com
The Utility of Neutrophil CD64 and Presepsin as Diagnostic, Prognostic, and Monitoring Biomarkers in Neonatal Sepsis
Heba E. Hashem ,1 Rania M. Abdel Halim,1 Sherin A. El Masry ,1 Amira M. Mokhtar ,1and Noureldin M. Abdelaal 2
1Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2Pediatric and Neonatology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Correspondence should be addressed to Heba E. Hashem; hebaezzat@med.asu.edu.eg
Received 9 July 2020; Revised 16 August 2020; Accepted 22 September 2020; Published 2 November 2020
Диагностическое и прогностическое значение уровня пресепсина при инфекционно-воспалительных заболеваниях у недоношенных новорожденных
Л.Н. Журавлева, В.И. НовиковаВитебский государственный медицинский университет
Diagnostic and prognostic value of the presepsin level in inflammatory infectious
diseases in preterm newborns
L.N. Zhuravleva, V.I. Novikova
Vitebsk State Medical University, Vitebsk, Belarus
Presepsin as a New Marker for Early Detection Neonatal Sepsis in Al-Quwayiyah General Hospital Riyadh, KSA
2Microbiology Laboratory, Al-Quwayiyah General Hospital, Riyadh, KSA.
3Department of Pediatrics, Faculty of Medicine, Benha University, Egypt.
4Nursery Department, Al-Quwayiyah General Hospital, Riyadh, KSA.а
The combination of procalcitonin and C-reactive protein or presepsin alone improves the accuracy of diagnosis of neonatal sepsis: a meta-analysis and systematic review
Lin Ruan1*, Guan-Yu Chen1, Zhen Liu1,2†, Yun Zhao1,2†, Guang-Yu Xu1,2†, Shu-Fang Li1,2†, Chun-Ni Li1,2†,Lin-Shan Chen1,3† and Zheng Tao1,3†
Presepsin and fetuin-A dyad for the diagnosis of proven sepsis in preterm neonates
Halil Değirmencioğlu1, Buse Ozer Bekmez2* , Turan Derme2, Mehmet Yekta Öncel3, Fuat Emre Canpolat2 andДиагностические характеристики пресепсина при позднем неонатальном сепсисе у недоношенных новорожденных.
Пограничный уровень - 823 пг/мл
Чувствительность – 88,9%; специфичность – 88,9%, AUC ROC – 0,939;
Положительное предиктивное значение – 72,7%
Отрицательное предиктивное значение - 87,5 %
Soluble CD14 subtype (sCD14-ST) as biomarker in neonatal early-onset sepsis and late-onset sepsis: a systematic review and meta-analysis
Iris van Maldeghem , Charlotte M. Nusman and Douwe H. Visser
1Department of Pediatrics, Emma Children’s Hospital, Amsterdam UMC,
University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
Full list of author information is available at the end of the article.
«Пресепсин (sCD14-ST) как биомаркер раннего и позднего неонатального сепсиса: систематический обзор и мета-анализ» ПСП – многообещающий маркер раннего и позднего неонатального сепсиса (РНС и ПНС). Разница между средними уровнями ПСП при РНС и ПНС подчеркивает важность того, что РНС и ПНС это две различные патологические сущности (different disease entities), при которых образцы измеренные при РНС характеризуют преклиническую стадию инфекции, а при ПНС - ее клиническую стадию. В будущей ежедневной практике ПСП может быть ценным маркером для исключения РНС до начала антибиотикотерапии.
The emerging role of Presepsin for diagnosis and monitoring of neonatal sepsis
Mitsubishi Chemical Europe GmbHWillstätter Str. 30, 40549 Düsseldorf, Germany
Phone: +49 (0) 211 - 5 20 54 10
Facsimile: +49 (0) 211 - 59 12 72
email: Pathfast@mc-e.de
The Physiological Variation in Plasma Presepsin Levels During the Early Neonatal Period
Masahiro Ishii, 1 Takayuki Hoshina, 1 Shun Ichikawa, 1 Daisuke Shimizu, 1Shunsuke Araki, 1 Tadamune Kinjo, 1 Eiji Shibata, 2 Toru Hachisuga 2 and Koichi Kusuhara 1
1 Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Japan,
Kitakyushu, Fukuoka, Japan
2 Department of Obstetrics and Gynecology, School of Medicine, University of Occupational and Environmental
Health, Japan, Kitakyushu, Fukuoka, Japan
The combination of procalcitonin and C-reactive protein or presepsin alone improves the accuracy of diagnosis of neonatal sepsis: a meta-analysis and systematic review
Lin Ruan 1* , Guan-Yu Chen 1 , Zhen Liu 1,2† , Yun Zhao 1,2† , Guang-Yu Xu 1,2† , Shu-Fang Li 1,2† , Chun-Ni Li 1,2† , Lin-Shan Chen 1,3† and Zheng Tao 1,3†† Zhen Liu, Yun Zhao, Guang-Yu Xu, Shu-Fang Li, Chun-Ni Li, Lin-Shan Chen and Zheng Tao contributed equally to this work.
1 Departments of Anesthesiology, Guangxi Medical University Affiliated Tumor Hospital, Naning, Guangxi, China
Full list of author information is available at the end of the article
The role of presepsin, c-reactive protein and procalcitonin as a marker of therapy response and prognosis for late onset neonatal sepsis in preterm neonates
Dalima AW Astrawinata 1 , Risma Kerina Kaban 2 , Rosalina Dewi Roeslani 3 , Erna Parmawati 41 Department of Clinical Pathology, Faculty of Medicine University Indonesia/Dr. Cipto Mangunkusumo National General Hospital, Jakarta
2 Department of Pediatric, Faculty of Medicine University Indonesia/Dr. Cipto Mangunkusumo National General Hospital, Jakarta
3 Department of Pediatric, Faculty of Medicine University Indonesia/Dr. Cipto Mangunkusumo National General Hospital, Jakarta
4 Department of Clinical Pathology Medical Specialty Program, Faculty of Medicine University Indonesia/Dr.Cipto
Mangunkusumo National General Hospital, Jakarta.
Новый высокочувствительный и высокоспецифичный маркер неонатального сепсиса - пресепсин
Д.Ж. БАТЫРБАЕВА, Б.А. РАМАЗАНОВА, А. БЕКНАЗАРОВА, Ж.С. АЛИБАЕВА, А.А. АБДРАИМОВАА.Д. НУРАХОВА, Н.К. ИБРАЕВА, Р.С. БАТЫРХАНОВА
Казахский Национальный медицинский университет им. С.Д. Асфендиярова, НИИ ПФМ им. Б.А. Атшабарова,
Научная клинико-диагностическая лаборатория
Diagnostic Accuracy of Presepsin (sCD14-ST) for Prediction of Bacterial Infection in Cerebrospinal Fluid Samples from Children with Suspected Bacterial Meningitis or Ventriculitis
David Stubljar,a Andreja Natasa Kopitar,a Mojca Groselj-Grenc,b Kristina Suhadolc,c Teja Fabjan,c Miha SkvarcaInstitute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Sloveniaa; Department of Paediatric Surgery and Intensive Care,
University Medical Centre Ljubljana, Ljubljana, Sloveniab; Clinical Institute of Clinical Chemistry and Biochemistry, University Medical Centre Ljubljana, Ljubljana, Sloveniac
The clinical significance of sCD14-ST for blood biomarker in neonatal hematosepsis
Ting Xiao, Master’s Degreea, Li-Ping Chen, Master’s Degreea, Li-hua Zhang, Bachelor’s Degreeb,Fu-Huang Lai, Bachelor’s Degreeb, Li Zhang, Bachelor’s Degreeb, Qun-feng Qiu, Bachelor’s Degreea,
Rong-Liang Que, Bachelor’s Degreea, SiSi Xie, Master’s Degreea, Ding-Chang Wu, Bachelor’s Degreea,∗
Биологические маркеры в диагностике и лечении сепсиса (обзор литературы)
А. А. Звягин, В. С. Демидова, Г. В. СмирновФГБУ «Институт хирургии им. А. В. Вишневского» Минздрава России; Россия, 117997, Москва, ул. Большая Серпуховская, 27
Контакты: Альфред Аркадьевич Звягин zvyagin@ixv.ru
Diagnostic and Prognostic Value of Presepsin for Subclinical Chorioamnionitis in Pregnancies between 23-28 Week with Preterm Premature Rupture of the Membranes
Erbil Çakar¹, Şule Eren Çakar², Habibe Ayvacı Taşan¹, Deniz Karçaaltıncaba³, Mehmet Baki Şentürk¹,Nermin Koç4, Ramazan Uluhan5
¹Department of Obstetrics and Gynecology, Zeynep Kamil Gynecologic and Pediatric Training and Research Hospital, İstanbul, Turkey
²Deparment of Infectious Diseases, Ümraniye Training and Research Hospital, İstanbul, Turkey
³Department of Obstetrics and Gynecology, Gazi University School of Medicine, Ankara, Turkey
4Department of Pathology, Zeynep Kamil Gynecologic and Pediatric Training and Research Hospital, İstanbul, Turkey
5Department of Clinical Microbiology, Zeynep Kamil Gynecologic and Pediatric Training and Research Hospital, İstanbul, Turkey
Пресепсин – ранний и надежный диагностический и прогностический маркер неонатального сепсиса
Jehan H Sabry1, Osama A Elfeky2, Akram E Elsadek3, Ahmed A Eldaly4.1. Assistant Professor of Clinical & Chemical Pathology, Benha Faculty of Medicine, Egypt.
2. Professor of Pediatrics, Benha Faculty of Medicine, Egypt.
3. Lecturer of Pediatric, Benha Faculty of Medicine, Egypt.
4. Resident of Pediatrics, Ministry of Health, Egypt.
Presepsin as an important diagnostic biomarker that differentiates sepsis from non-infectious SIRS in critical ill adult patients: A system review and meta-analysis
Dan Xie1 †, Kunpeng Hu2 †, Purun Lei3, Ying Xian1, Ying Wang1, Xiaogang Bi1, Kouxing Zhang1**Correspondence: Professor Kouxing Zhang, Department of General ICU of Lingnan Hospital, The Third Affiliated Hospital, Sun Yat-sen
University, Guangzhou, China,
Presepsin (Soluble CD14 Subtype): Reference Ranges of a New Sepsis Marker in Term and Preterm Neonates
Lorenza Pugni1*, Carlo Pietrasanta1, Silvano Milani2, Claudia Vener2, Andrea Ronchi1,Mariella Falbo1, Milena Arghittu3, Fabio Mosca1
1 NICU, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca’ Granda Ospedale
Maggiore Policlinico, University of Milan, Milan, Italy, 2 Laboratory “GA Maccacaro”, Department of Clinical
Sciences and Community Health, University of Milan, Milan, Italy, 3 Microbiology Laboratory, Fondazione
IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
Soluble CD14-subtype (Prespsin) and Hepcidin as Diagnostic and Prognostic markers in Early Onset Neonatal Sepsis
1Tawfik Abdel Motalib*, 2Fatma A Khalaf , 3Ghada El Hendawy,4Sobhy E Kotb, 5Aml M Ali, 6Amal El Sharnoby
Departments of 1Microbiology, 2Clinical Biochemistry & 6Clinical Pathology, National Liver Institute, Menoufiya
University; 3Microbiology Department, Faculty of Medicine - Menoufiya University; Departments of Pediatric,
4Dubai Hospital & 5Ahmed Maher Teaching Hospital
Diagnostic Value of Presepsin (Scd14-St Subtype) Evaluation in the Detection of Severe Neonatal Infections
Stojewska Małgorzata Department of Pediatrics Zabrze, Silesian Medical University Katowice, PolandBehrendt Jakub, Szymańska Anna, Pukas-Bochenek Anna, Stachurska Aneta, Godula – Stuglik Urszula Department of Neonatal Intensive Care Units Zabrze, Silesian Medical University Katowice, Poland
Mazur Bogdan Depatrment of Microbiology and Immunology Zabrze, Silesian Medical University Katowice, Poland
Presepsin (soluble CD14 subtype) in term and preterm newborns
Lorenza Pugni1, Carlo Pietrasanta1, Mariella Falbo1, Tania Todorovic1, Claudia Vener2, SilvanoMilani2, Fabio Mosca1
1NICU, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca’ Granda
Ospedale Maggiore Policlinico, University of Milan, Milan, Italy 2Medical Statistics and
Biometrics Unit, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca’
Granda, Ospedale Maggiore Policlinico, University of Milan, Milan, Italy
Early Human Development, Volume 90, Supplement 2, Pages S64–S65, September 2014
Diagnostic and prognostic value of presepsin in preterm deliveries
Abstracts / Journal of Reproductive Immunology 101–102 (2014) 40–60Karin Malícˇková1,∗, Michal Koucky´ 2, Antonín Parˇízek2,
Kvˇeta Pelinková1, Helena Brodská1, Zdenˇek Hájek2, Anna
Germanová2, Oto Mestek3, Tomáˇs Zima1
1 Institute of Medical Biochemistry and Laboratory Diagnostics,
General University Hospital and 1st Faculty of Medicine
of Charles University in Prague, Czech Republic
2 Department of Gynecology and Obstetrics, General University
Hospital and 1st Faculty of Medicine of Charles University
in Prague, Czech Republic
3 Institute of Chemical Technology Prague, Czech Republic