Presepsin (soluble CD14 subtype) in term and preterm newborns

Background: Sepsis is a major cause of morbidity and mortality in newborns, especially in preterm infants. Several biochemical markers (C-reactive protein, procalcitonin, interleukin-6, etc.) have been proposed over the past years to diagnose and manage neonatal sepsis. However, these markers have a low diagnostic accuracy in neonatal infections. Recently, presepsin (soluble CD14 subtype, sCD14-ST), a circulating molecule fragment derived from sCD14, has been shown to be beneficial as sepsis marker. Nevertheless, few data are available on the usefulness of presepsin in the diagnosis of neonatal sepsis.